کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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6217369 | 1273761 | 2014 | 5 صفحه PDF | دانلود رایگان |
PurposeIntestinal vasoconstriction is a critical step in development of necrotizing enterocolitis (NEC). Relaxin (RLXN), a hormone found in breast milk but absent from formula, is a potent vasodilator. We hypothesized that relaxin-supplemented feeds with an NEC protocol would decrease NEC severity and increase intestinal blood flow.MethodsTimed-pregnant Sprague-Dawley rats were randomly assigned to CONTROL, NEC, NECÂ +Â 1xRLXN, or NECÂ +Â All Feeds RLXN, and all but CONTROL underwent NEC protocol. NECÂ +Â 1xRLXN and NECÂ +Â All Feeds RLXN groups were fed relaxin-supplemented formula with the last feed or every feed. At 48Â h of life, intestinal blood flow was measured at baseline and after application of 2.5% Delflex® solution.ResultsThe addition of relaxin to NEC group feeds (1x or All Feeds) improved the degree of ileal injury. Ileal blood flow was decreased in the NEC pups compared to the CONTROLS, but the addition of relaxin to one feed increased baseline ileal blood flow in the NEC group compared to NEC alone. Furthermore, the addition of relaxin to ALL feeds significantly increased baseline ileal blood flow.ConclusionPups who received relaxin with all feeds had substantially increased ileal perfusion compared to control pups. Our data suggest that relaxin supplementation maintains intestinal blood flow and results in less histologic NEC.
Journal: Journal of Pediatric Surgery - Volume 49, Issue 6, June 2014, Pages 961-965