کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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6219056 | 1607432 | 2016 | 12 صفحه PDF | دانلود رایگان |

ObjectiveTo evaluate whether large for gestational age (LGA) etiological subgroups have differential growth trajectories during early childhood.Study designApproximately 10â700 infants and their parents were included in the Early Childhood Longitudinal Study-Birth Cohort in 2001-2002. Research staff collected data in 5 waves when participating children were approximately 9Â months and 2, 4, 5, and 6Â years of age. We analyzed 2950 LGA and appropriate-for-gestational-age (AGA) children with at least 1 growth outcome at ages 9Â months, 2Â years, and 4Â years. We divided 600 LGA newborns into 8 subgroups by maternal overweight or obesity before pregnancy (OW/OB), diabetes mellitus (DM), and excessive gestational weight gain (ExGWG). We used mixed effect regression models to compare trajectories of height (length)-for-age or body mass index (BMI) z scores across LGA subgroups and the AGA reference group.ResultsRelative to the reference group, the LGA subgroup with maternal OW/OB and DM but normal gestational weight gain had “continuous high rising” BMI z-score trajectory from 9Â months to 4Â years and the greatest mean z score at 4Â years (2.14 [95% CI, 1.29, 2.98]). The LGA subgroup free of maternal OW/OB, DM, or ExGWG had a similar BMI z-score trajectory (“stable low”) from 9Â months to 4Â years and a similar 4-years mean z score (0.97 [95% CI, 0.75, 1.18] vs 0.72 [95% CI, 0.67, 0.78]) relative to the AGA reference group.ConclusionsThe LGA subgroup with co-occurrence of maternal OW/OB and DM had the greatest 4-year BMI, whereas the LGA subgroup free of maternal OW/OB, DM, or ExGWG were tall but lean (“a healthy phenotype”).
Journal: The Journal of Pediatrics - Volume 170, March 2016, Pages 60-66.e5