کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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6219352 | 1607426 | 2016 | 10 صفحه PDF | دانلود رایگان |
ObjectiveTo investigate the longitudinal effects of perinatal exposure to dioxin on neurodevelopment and physical growth of a birth cohort during the first 3Â years of life.Study designA total of 217 mother-infant pairs living in a dioxin-contaminated area in Vietnam were followed up. Perinatal dioxin exposure of infants was estimated by the measurement of dioxin levels in breast milk of nursing mothers. Neurodevelopment of infants and children, including cognitive, language, and motor development, was determined at 4Â months, 1Â year, and 3Â years of age. Physical growth, including weight, height, and head and abdominal circumferences, was measured at birth, 1 and 4Â months, and 1 and 3Â years of age. Multivariate mixed models were applied for analyzing repeated measures.ResultsIn boys, composite motor and gross motor scores were decreased with increasing exposure of 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TetraCDD). The high toxic equivalent of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDDs/PCDFs-TEQ) group showed a significant decrease in expressive communication score. In girls, there was no decreased score in any neurodevelopment aspects in high-exposure groups. All body size measures in boys were decreased in the high-exposure groups of 2,3,7,8-TetraCDD and PCDDs/PCDFs-TEQ. In girls, high 2,3,7,8-TetraCDD and PCDDs/PCDFs-TEQ exposure was associated with increased head and abdominal circumferences.ConclusionsPerinatal dioxin exposure affects physical growth and neurodevelopment of infants and children in the first 3Â years of life in a sex-specific manner.
Journal: The Journal of Pediatrics - Volume 175, August 2016, Pages 159-166.e2