کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6219696 1607435 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Severe Congenital Heart Defects Are Associated with Global Reduction of Neonatal Brain Volumes
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پریناتولوژی (پزشکی مادر و جنین)، طب اطفال و بهداشت کودک
پیش نمایش صفحه اول مقاله
Severe Congenital Heart Defects Are Associated with Global Reduction of Neonatal Brain Volumes
چکیده انگلیسی

ObjectivesTo determine neonatal global and regional brain volumes in infants with congenital heart disease (CHD) in comparison with healthy controls and to determine brain growth.Study designProspective cohort study in infants undergoing open-heart surgery for complex CHD. Global and regional volumetric measurements on preoperative cerebral magnetic resonance imaging were manually segmented in children without overt brain lesions.ResultsPreoperative brain volumetry of 19 patients demonstrates reduction in total and regional brain volumes, without any specific regional predilection compared with 19 healthy control infants (total brain volume reduction: 21%, regional brain volume reduction 8%-28%, all P < .001).ConclusionsInfants with CHD undergoing bypass surgery have smaller brain volumes prior to surgery without a specific regional predilection. This suggests a fetal origin of reduced brain growth.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Pediatrics - Volume 167, Issue 6, December 2015, Pages 1259-1263.e1
نویسندگان
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