کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6220796 | 1607442 | 2015 | 7 صفحه PDF | دانلود رایگان |
ObjectiveTo investigate the total peripheral vascular resistance (TPVR), cardiac output (CO), and plasma C-type natriuretic peptide (CNP) levels in children with postural tachycardia syndrome (POTS) during supine, upright, and return to supine.Study designTwenty-nine children with POTS, aged 12 ± 3 years, were recruited, and 32 healthy children, aged 11 ± 2 years, served as controls. Heart rate (HR), blood pressure, TPVR, and CO were continuously monitored with Finapres Medical System, and plasma CNP levels were detected with Sandwich immunoluminescence assay.ResultsIn children with POTS, upright TPVR and CO were significantly lower than those in supine position, and they rose again when they returned to supine position. However, in healthy control patients, both TPVR and CO did not change during supine, upright, and supine again positions. Also, in the supine position, there was no significant difference in TPVR and CO between POTS children and control subjects (P > .05). When upright, however, TPVR and CO in children with POTS were significantly lower than those of controls. Plasma CNP levels were significantly greater in children with POTS than that of controls (32.8 ± 9.7 vs 24.2 ± 8.4 [pg/mL], P < .01), and symptom scores and ÎHR positively correlated with plasma CNP levels in children with POTS (symptom scores: r = 0.490, P < .01; ÎHR: r = 0.508, P < .001), but CO negatively correlated with plasma CNP levels (r = â0.446, P < .01).ConclusionReduced TPVR and CO associated with the elevated plasma CNP might be involved in the pathogenesis of POTS.
Journal: The Journal of Pediatrics - Volume 166, Issue 6, June 2015, Pages 1385-1389.e2