کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6221269 1607445 2015 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Unbound Unconjugated Hyperbilirubinemia Is Associated with Central Apnea in Premature Infants
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پریناتولوژی (پزشکی مادر و جنین)، طب اطفال و بهداشت کودک
پیش نمایش صفحه اول مقاله
Unbound Unconjugated Hyperbilirubinemia Is Associated with Central Apnea in Premature Infants
چکیده انگلیسی

ObjectiveTo evaluate whether jaundice, indexed by unbound bilirubin (UB), is associated with central apnea in premature infants.Study designA prospective observational study was performed with 27-33 weeks' gestational age infants who were not requiring either mechanical ventilation or noninvasive ventilation with continuous positive airway pressure beyond 24 hours after birth. Infants with congenital infections, chromosomal disorders, craniofacial anomalies, and/or family history of hearing loss were excluded. Total serum bilirubin and UB were measured twice daily during the first postnatal week and then when clinically indicated. Central apnea was evaluated by visual inspection of continuous, electronic cardiorespiratory recordings until 2 weeks of age.ResultsOne hundred infants were subdivided into 2 groups via median peak UB level: the high UB group (greater than median) and low UB group (less than median). The high UB group had an increased frequency of apnea events during the first 2 weeks compared with infants in the low UB group. After we controlled for confounders, the high UB group had more events of apnea during the first 2 postnatal weeks compared with the low UB group (incidence rate ratio: 1.9, 95% CI 1.2-3.2).ConclusionsOur findings suggest that jaundice, as indexed by UB, is associated with central apnea in premature infants.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Pediatrics - Volume 166, Issue 3, March 2015, Pages 571-575
نویسندگان
, , ,