کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6224521 1607482 2012 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Placenta-Imprinted Gene Expression Association of Infant Neurobehavior
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پریناتولوژی (پزشکی مادر و جنین)، طب اطفال و بهداشت کودک
پیش نمایش صفحه اول مقاله
Placenta-Imprinted Gene Expression Association of Infant Neurobehavior
چکیده انگلیسی

ObjectiveTo identify links between altered gene imprinting in the placenta and infant neurobehavioral profiles.Study designQuantitative reverse-transcription polymerase chain reaction was used to examine the expression of 22 imprinted candidate genes in a series of 106 term human primary placenta tissues. The expression pattern uncovered was associated with Neonatal Intensive Care Unit Network Neurobehavioral Scales summary scores in the corresponding infants. Clustering of the expression data was used to define distinct classes of expression.ResultsSignificant associations were identified between classes of expression and the Neonatal Intensive Care Unit Network Neurobehavioral Scales quality of movement (P = .02) and handling (P = .006) scores. Multivariate regression demonstrated an independent effect of imprinted gene expression profile on these neurobehavioral scores after controlling for confounders.ConclusionThese results suggest that alterations in imprinted gene expression in the placenta are associated with infant neurodevelopmental outcomes, and suggest a role for the placenta and genomic imprinting in the placenta beyond intrauterine growth regulation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Pediatrics - Volume 160, Issue 5, May 2012, Pages 854-860.e2
نویسندگان
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