کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6224880 1607480 2012 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Epidemiologic and Clinical Features of Other Enteric Viruses Associated with Acute Gastroenteritis in American Indian Infants
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پریناتولوژی (پزشکی مادر و جنین)، طب اطفال و بهداشت کودک
پیش نمایش صفحه اول مقاله
Epidemiologic and Clinical Features of Other Enteric Viruses Associated with Acute Gastroenteritis in American Indian Infants
چکیده انگلیسی

ObjectiveTo investigate the viral etiology, through the use of molecular methods, of acute gastroenteritis (AGE), which is a considerable public health burden in Native American infants.Study designFrom March 2002 through February 2004, AGE and non-diarrheal stools were collected from Navajo and White Mountain Apache infants who received placebo during a rotavirus vaccine trial. Case (n = 247) and control (n = 344) specimens were tested for enteric adenovirus, astrovirus, norovirus, rotavirus, and sapovirus with real-time polymerase chain reaction. The odds of AGE were compared with population-averaged logistic regression models.ResultsIn 65% of the cases of AGE (161/247), at least one virus was detected; norovirus (n = 80, 32%) and rotavirus (n = 70, 28%) were the most common. A virus was detected in 38% of control specimens (132/344). Detection of “any virus” was associated with AGE (OR = 3.22; 95% CI, 2.11-4.91), as was detection of norovirus (OR = 2.00; 95% CI, 1.22-3.26) and rotavirus (OR = 2.69; 95% CI, 1.52-4.79).ConclusionThis study highlights the significant burden of viral AGE in American Indian infants and identifies pathogen targets for future prevention efforts in this population.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Pediatrics - Volume 161, Issue 1, July 2012, Pages 110-115.e1
نویسندگان
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