کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6255898 | 1612922 | 2016 | 46 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Enhanced attention and impulsive action following NMDA receptor GluN2B-selective antagonist pretreatment
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کلمات کلیدی
DRLPALPCPGluN2BNMDAITI5-CSRTTN-methyl d-aspartateRGTBehavioural flexibility - انعطاف پذیری رفتاریcompulsivity - تسخیرOccupancy - تصرفimpulsivity - تکانشگریPaired associate learning - زوج یادگیری همکارPhencyclidine - فن سیکلیدین، گرد فرشتهStimulus duration - مدت زمان تحریکRat - موش صحرایی5-choice serial reaction time task - کار 5 بار واکنش سریال واکنش
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Enhanced attention and impulsive action following NMDA receptor GluN2B-selective antagonist pretreatment Enhanced attention and impulsive action following NMDA receptor GluN2B-selective antagonist pretreatment](/preview/png/6255898.png)
چکیده انگلیسی
NMDA GluN2B (NR2B) subtype selective antagonists are currently in clinical development for a variety of indications, including major depression. We previously reported the selective NMDA GluN2B antagonists Ro 63-1908 and traxoprodil, increase premature responding in a 5-choice serial reaction time task (5-CSRTT) suggesting an effect on impulsive action. The present studies extend these investigations to a Go-NoGo and delay discounting task, and the 5-CSRTT under test conditions of both regular (5Â s) and short (2-5Â s) multiple ITI (Intertrial interval). Dizocilpine was included for comparison. Both Ro 63-1908 (0.1-1Â mg/kg SC) and traxoprodil (0.3-3Â mg/kg SC) increased premature and perseverative responses in both 5-CSRT tasks and improved attention when tested under a short ITI test condition. Ro 63-1908 but not traxoprodil increased motor impulsivity (false alarms) in a Go-NoGo task. Dizocilpine (0.01-0.06Â mg/kg SC) affected both measures of motor impulsivity and marginally improved attention. In a delay discounting test of impulsive choice, both dizocilpine and Ro 63-1908 decreased impulsive choice (increased choice for the larger, delayed reward), while traxoprodil showed a similar trend. Motor stimulant effects were evident following Ro 63-1908, but not traxoprodil treatment â although no signs of motor stereotypy characteristic of dizocilpine (>0.1Â mg/kg) were noted. The findings of both NMDA GluN2B antagonists affecting measures of impulsive action and compulsive behavior may underpin emerging evidence to suggest glutamate signaling through the NMDA GluN2B receptor plays an important role in behavioural flexibility. The profiles between Ro 63-1908 and traxoprodil were not identical, perhaps suggesting differences between members of this drug class.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Behavioural Brain Research - Volume 311, 15 September 2016, Pages 1-14
Journal: Behavioural Brain Research - Volume 311, 15 September 2016, Pages 1-14
نویسندگان
Guy A. Higgins, Leo B. Silenieks, Cam MacMillan, Julia Sevo, Fiona D. Zeeb, Sandy Thevarkunnel,