کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6256009 | 1612925 | 2016 | 8 صفحه PDF | دانلود رایگان |
- We found early immature neuronal death, which was determined by DCX and NeuN-double-staining.
- Injection of caspase-3 inhibitor rescued cells from immature neuronal death.
- z-DEVD-fmk treatment partially rescued ischemia-induced spatial memory impairment.
- Ischemia-induced LTP impairment in the perforant pathway was restored by z-DEVD-fmk treatment.
Memory impairment is a common after an ischemic stroke. While delayed neuronal death in the CA1 region is usually linked to cerebral ischemia-induced memory impairment, the role of early immature neuronal death within the DG region in the memory state of an ischemic stroke model has rarely been studied. Here, we show a partial role of immature neuronal death in memory impairment in a global ischemia model. We found early immature neuronal death, which was determined by DCX and NeuN-double-staining. Injection of z-DEVD-fmk, a caspase-3 inhibitor, into the DG region rescued cells from immature neuronal death in the DG region without affecting delayed neuronal death in the CA1 region of an ischemic brain. Moreover, z-DEVD-fmk treatment partially rescued ischemia-induced spatial memory impairment. We also found that ischemia-induced LTP impairment in the perforant pathway was restored by z-DEVD-fmk treatment. These results suggest that early immature neuronal death is partially involved in ischemia-induced spatial memory impairment.
Journal: Behavioural Brain Research - Volume 308, 15 July 2016, Pages 75-82