کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6256253 | 1289914 | 2016 | 11 صفحه PDF | دانلود رایگان |
- Post-training irradiation enhances contextual fear memory.
- This is associated with reduced neuronal activation in the infralimbic cortex.
- This involves reduced GABA-ergic neurotransmission in the infralimbic cortex.
The brain might be exposed to irradiation under a variety of situations, including clinical treatments, nuclear accidents, dirty bomb scenarios, and military and space missions. Correctly recalling tasks learned prior to irradiation is important but little is known about post-learning effects of irradiation. It is not clear whether exposure to X-ray irradiation during memory consolidation, a few hours following training, is associated with altered contextual fear conditioning 24Â h after irradiation and which brain region(s) might be involved in these effects. Brain immunoreactivity patterns of the immediately early gene c-Fos, a marker of cellular activity was used to determine which brain areas might be altered in post-training irradiation memory retention tasks. In this study, we show that post-training gamma irradiation exposure (1Â Gy) enhanced contextual fear memory 24Â h later and is associated with reduced cellular activation in the infralimbic cortex. Reduced GABA-ergic neurotransmission in parvalbumin-positive cells in the infralimbic cortex might play a role in this post-training radiation-enhanced contextual fear memory.
Journal: Behavioural Brain Research - Volume 298, Part B, 1 February 2016, Pages 1-11