کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6256370 1612935 2016 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Research reportRosmarinic acid prevents against memory deficits in ischemic mice
ترجمه فارسی عنوان
تحقیقات نشان می دهد اسید اساررینیک مانع از کمبود حافظه در موش های ایسکمیک می شود
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
چکیده انگلیسی


- Rosmarinic acid prevents memory deficits induced by permanent focal cerebral ischemia.
- Rosmarinic acid induced synaptogenesis in ischemic mice.
- Increased BDNF were observed in ischemic mice treated with rosmarinic acid.
- Rosmarinic acid diminished MPO activity and astrogliosis in ischemic mice.

Polyphenols have neuroprotective effects after brain ischemia. It has been demonstrated that rosmarinic acid (RA), a natural phenolic compound, possesses antioxidant and anti-inflammatory properties. To evaluate the effectiveness of RA against memory deficits induced by permanent middle cerebral artery occlusion (pMCAO) mice were treated with RA (0.1, 1, and 20 mg/kg/day, i.p. before ischemia and during 5 days). Animals were evaluated for locomotor activity and working memory 72 h after pMCAO, and spatial and recognition memories 96 h after pMCAO. In addition, in another set of experiments brain infarction, neurological deficit score and myeloperoxidase (MPO) activity were evaluates 24 h after the pMCAO. Finally, immunohistochemistry, and western blot, and ELISA assay were used to analyze glial fibrillary acidic protein (GFAP), and synaptophysin (SYP) expression, and BDNF level, respectively. The working, spatial, and recognition memory deficits were significantly improved with RA treatment (20 mg/kg). RA reduced infarct size and neurological deficits caused by acute ischemia. The mechanism for RA neuroprotection involved, neuronal loss suppression, and increase of synaptophysin expression, and increase of BDNF. Furthermore, the increase of MPO activity and GFAP immunireactivity were prevented in MCAO group treated with RA. These results suggest that RA exerts memory protective effects probably due to synaptogenic activity and anti-inflammatory action.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Behavioural Brain Research SreeTestContent1 - Volume 297, 15 January 2016, Pages 91-103
نویسندگان
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