کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6256427 1612935 2016 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Research reportMaternal separation facilitates extinction of social fear in adult male mice
ترجمه فارسی عنوان
گزارش تحقیقاتی جداسازی مادری باعث انقراض ترس اجتماعی در موش های نر بالغ می شود
کلمات کلیدی
استرس زودرس، ترس اجتماعی اجتماعی، تهدید ترسناک حافظه اجتماعی، حافظه غیر اجتماعی، اضطراب،
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
چکیده انگلیسی


- We use maternal separation (MS, on postnatal days 1-14) to induce early life stress.
- We use social fear conditioning to induce social fear in adult MS and control mice.
- Maternal separation facilitates extinction of social, but not of non-social fear.
- Early life stress improves recovery from a traumatic social experience in adulthood.

Early life stress, such as child abuse or neglect, is a risk factor for the development of psychopathologies characterized by abnormal social and emotional behaviors. In rodents, long-lasting changes in stress coping and emotional behavior can be induced by separating pups from their mother. We used maternal separation (MS; 3 h daily on postnatal days 1-14) to test whether early life stress alters acquisition and extinction of social fear in adult male mice as studied in a specific model of social fear, i.e., in the social fear conditioning paradigm. We show that MS facilitated extinction of social fear without altering acquisition or expression of social fear. This facilitatory effect of MS on social fear extinction was not due to improved social learning and memory abilities or to increased social interest, as MS rather impaired social memory in the social discrimination test and did not alter social preference in the social preference-avoidance test. In contrast, MS did not alter acquisition and extinction of non-social, cued fear, or non-social memory as assessed in the object discrimination test and non-social anxiety as assessed in the elevated plus-maze. These results suggest that a social stress like MS in early life may improve coping with and recovery from a traumatic social experience in adulthood in mice.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Behavioural Brain Research SreeTestContent1 - Volume 297, 15 January 2016, Pages 323-328
نویسندگان
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