کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6256517 1612940 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The voltage-gated sodium channel activator veratrine induces anxiogenic-like behaviors in rats
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
The voltage-gated sodium channel activator veratrine induces anxiogenic-like behaviors in rats
چکیده انگلیسی


- Systemically administered veratrine induced anxiety-like behaviors in the rat light/dark test.
- This finding was supported in the elevated-plus maze and tail-swing behavior tests.
- Veratrine increased plasma corticosterone concentrations in rat.
- Veratrine-induced anxiety-like behaviors were abolished by riluzole and diazepam.
- This model is a novel pathological animal model for exploring possible candidate drugs for anxiolytics.

In this study, we investigated the anxiogenic-like effects of systemically administered veratrine in rat models of anxiety. In the light/dark test, veratrine (0.6 mg/kg, s.c.) significantly and dose-dependently decreased the time rats spent in and the number of entries into a light box 30 min after administration, suggesting that veratrine increases anxiety-like behaviors. These findings were also supported by results from the elevated-plus maze test and the tail-swing behavior test. In addition, veratrine (0.6 mg/kg, s.c.) significantly increased the plasma concentration of corticosterone, an endogenous biomarker for anxiety, compared to vehicle. On the basis of these results, we conclude that veratrine induces anxiogenic-like behaviors in rats. The anxiogenic-like behaviors induced by veratrine (0.6 mg/kg, s.c.) were completely abolished by co-treatment with the typical benzodiazepine anxiolytic diazepam (1 mg/kg, s.c.), when assessed in the elevated-plus maze test. Similar results were obtained with co-treatment with riluzole (10 mg/kg, p.o.), which directly affects the glutamatergic system and has recently been suggested to have anxiolytic-like effects. In conclusion, this study provides evidence that systemically administered veratrine induces anxiogenic-like behaviors in rats. We propose the veratrine model as a novel pathological animal model to explore possible candidate drugs for anxiolytics.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Behavioural Brain Research - Volume 292, 1 October 2015, Pages 316-322
نویسندگان
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