کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6256663 | 1612942 | 2015 | 7 صفحه PDF | دانلود رایگان |
- We inactivated the rostral agranular insular cortex (RAIC) using baclofen/muscimol.
- RAIC inactivation reduced nicotine self-administration under fixed ratio-5 schedule.
- RAIC inactivation also attenuated cue-induced reinstatement of nicotine seeking.
- Food self-administration (fixed ratio-5 schedule) unaffected by RAIC inactivation.
Our prior work demonstrated the involvement of the caudal granular subregion of the insular cortex in a rat model of nicotine self-administration. Recent studies in various animal models of addiction for nicotine and other drugs have identified a role for the rostral agranular subregion (RAIC). The current research was undertaken to examine the involvement of the RAIC in a rat model of nicotine self-administration. We investigated the inactivating effects of local infusions of a γ-aminobutyric acid agonist mixture (baclofen/muscimol) into the RAIC on nicotine self-administration under a fixed-ratio 5 (FR-5) schedule and on reinstatement of nicotine seeking induced by nicotine-associated cues in rats. We also evaluated the effects of RAIC inactivation on food self-administration under an FR5 schedule as a control. Inactivation of the RAIC decreased nicotine, but not food, self-administration. RAIC inactivation also prevented the reinstatement, after extinction, of nicotine seeking induced by nicotine-associated cues. Our study indicates that the RAIC is involved in nicotine-taking and nicotine-seeking in rats. Modulating insular cortex function appears to be a promising approach for nicotine dependence treatment.
Journal: Behavioural Brain Research - Volume 290, 1 September 2015, Pages 77-83