کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6257133 1612946 2015 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Research reportRole of dopaminergic and serotonergic neurotransmitters in behavioral alterations observed in rodent model of hepatic encephalopathy
ترجمه فارسی عنوان
گزارش تحقیق نقش دوپامینرژیک و سروتونرژیک عصبی در تغییرات رفتاری مشاهده شده در مدل جوندگان آنسفالوپاتی کبد
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
چکیده انگلیسی


- Role of biogenic amines in behavioral deficits was investigated in HE.
- Decline in cognitive functions was coupled with a decrease in serotonin levels.
- Motor impairment was accompanied by a decrease in dopamine levels.
- Behavioral deficits were also accompanied with histopathological changes.

The present study was designed to evaluate the role of biogenic amines in behavioral alterations observed in rat model of hepatic encephalopathy (HE) following bile duct ligation (BDL). Male Wistar rats subjected to BDL developed biliary fibrosis after four weeks which was supported by altered liver function tests, increased ammonia levels and histological staining (Sirius red). Animals were assessed for their behavioral performance in terms of cognitive, anxiety and motor functions. The levels of dopamine (DA), serotonin (5-HT), epinephrine and norepinephrine (NE) were estimated in different regions of brain viz. cortex, hippocampus, striatum and cerebellum using HPLC along with activity of monoamine oxidase (MAO). Cognitive assessment of BDL rats revealed a progressive decline in learning, memory formation, retrieval, exploration of novel environment and spontaneous locomotor activity along with decrease in 5-HT and NE levels. This was accompanied by an increase in MAO activity. Motor functions of BDL rats were also altered which were evident from decrease in the time spent on the rotating rod and higher foot faults assessed using narrow beam walk task. A global decrease was observed in the DA content along with an increase in MAO activity. Histopathological studies using hematoxylin-eosin (H&E) and cresyl violet exhibited marked neuronal degeneration, wherein neurons appeared more pyknotic, condensed and damaged. The results reveal that dopaminergic and serotonergic pathways are disturbed in chronic liver failure post-BDL which may be responsible for behavioral impairments observed in HE.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Behavioural Brain Research - Volume 286, 1 June 2015, Pages 222-235
نویسندگان
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