Short CommunicationChronic unpredictable stress during adolescence causes long-term anxiety

- Stress during adolescence causes a long-term increase in anxiety.
- Increased hyponeophagia is evident 196 days after exposure to unpredictable stress.
- Behavioral changes are not mediated by altered basal corticoid “stress” hormones.

Exposure to stress during adolescence can cause long-term changes in behavior and cognition. Anxiety diagnoses rise during adolescence and are increased by adverse experiences. Currently, it is unknown how long stress during adolescence alters anxiety in adulthood. We found that rats exposed to chronic unpredictable stress during adolescence expressed altered behavior 6.5 months later; showing increased anxiety in a feeding test in a novel environment. Although behavioral changes indicative of anxiety were detected in late adulthood, the basal levels of fecal corticoid metabolites in prior-stressed rats did not differ from unstressed, control rats.