کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6257749 1612958 2014 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Research reportLevels of central oxytocin and glucocorticoid receptor and serum adrenocorticotropic hormone and corticosterone in mandarin voles with different levels of sociability
ترجمه فارسی عنوان
گزارش تحقیق: مقادیر هورمون اکسیتوسین مرکزی و گلوکوکورتیکوئید و هورمون آدرنوکورتیکوتروپیک سرم و کورتیکوسترون سرم در اسپانای ماندارین با سطوح مختلف جامعه شناسی
کلمات کلیدی
اولویت اجتماعی، اجتناب از اجتماعی، اکسی توسین، گیرنده گلوکوکورتیکوئید، اسپری ماندارین،
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
چکیده انگلیسی


- Low social voles display higher levels of anxiety.
- Low social voles display more serum ACTH and CORT.
- High social voles display more GR-ir neurons in the hippocampus.
- High social voles display more OT-ir neurons in the PVN and SON.

Sociability is the prerequisite to social living. Oxytocin and the hypothalamo-pituitary-adrenocortical axis mediate various social behaviors across different social contexts in different rodents. We hypothesized that they also mediate levels of non-reproductive social behavior. Here we explored naturally occurring variation in sociability through a social preference test and compared central oxytocin, glucocorticoid receptors, serum adrenocorticotropic hormone and corticosterone in mandarin voles with different levels of sociability. We found that low-social voles showed higher levels of anxiety-like behavior in open field tests, and had more serum adrenocorticotropic hormone and corticosterone than high-social voles. High-social individuals had more glucocorticoid receptor positive neurons in the hippocampus and more oxytocin positive neurons in the paraventricular nuclei and supraoptic nuclei of the hypothalamus than low-social individuals. Within the same level of sociability, females had more oxytocin positive neurons in the paraventricular nuclei and supraoptic nuclei of the hypothalamus than males. These results indicate that naturally occurring social preferences are associated with higher levels of central oxytocin and hippocampus glucocorticoid receptor and lower levels of anxiety and serum adrenocorticotropic hormone and corticosterone.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Behavioural Brain Research - Volume 274, 1 November 2014, Pages 226-234
نویسندگان
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