کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6258597 | 1612973 | 2014 | 8 صفحه PDF | دانلود رایگان |
- 16 days of wheel running decreased ethanol consumption, with no effect on saccharin consumption.
- Changes in expression of midbrain Slc18a2 due to ethanol were dependent on running.
- Running and ethanol consumption had opposing effects on hippocampal Bdnf expression.
- Striatal expression of Drd1a was depressed by both running and ethanol.
The mesolimbic dopaminergic pathway has been implicated in many rewarding behaviors, including the consumption of ethanol and voluntary exercise. It has become apparent that different rewarding stimuli activate this pathway, and therefore it is possible for these behaviors to influence each other, i.e. hedonic substitution. Using adult female C57BL/6J mice, we demonstrate that voluntary access to a running wheel substantially reduces the consumption and preference of ethanol. Furthermore, we examined gene expression of several genes involved in regulating the mesolimbic dopaminergic pathway, which we hypothesized to be the main pathway involved in hedonic substitution. In the striatum, we observed a reduction in mRNA expression of Drd1a due to exercise. Hippocampal Bdnf mRNA increased in response to exercise and decreased in response to ethanol. Furthermore, there was an interaction effect of exercise and ethanol on the expression of Slc18a2 in the midbrain. These data suggest an important role for this pathway, and especially for Bdnf and Slc18a2 in regulating hedonic substitution.
Journal: Behavioural Brain Research - Volume 259, 1 February 2014, Pages 313-320