کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
6258650 1612979 2013 11 صفحه PDF سفارش دهید دانلود رایگان
عنوان انگلیسی مقاله ISI
Research reportAlterations in affective behavior during the time course of alcohol hangover
ترجمه فارسی عنوان
گزارش تحقیقاتی در زمینه رفتارهای عاطفی طی دوره غیبت الکل
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موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
چکیده انگلیسی


- Anxiety-like behavior and fear-related signs are evidenced during alcohol hangover.
- Signs of depression were found 14 h after hangover onset.
- Pain perception disabilities were detected at the beginning of hangover.
- Changes in affective behavior are evidenced for 14-16 h during hangover.

Alcohol hangover is a temporary state described as the unpleasant next-day effects after binge-like drinking. Hangover begins when ethanol is absent in plasma and is characterized by physical and psychological symptoms. Affective behavior is impaired during the acute phase of alcohol intoxication; however, no reports indicate if similar effects are observed during withdrawal. The aim of this work was to study the time-extension and possible fluctuations in affective behavior during a hangover episode. Male Swiss mice were injected i.p. either with saline (control group) or with ethanol (3.8 g/kg BW) (hangover group). Anxiety, fear-related behavior and despair phenotype were evaluated at a basal point (ZT0) and every 2 h up to 20 h after blood alcohol levels were close to zero (hangover onset). Also, anhedonia signs and pain perception disabilities were studied. Mice exhibited an increase in anxiety-like behavior during 4 h and 14 h after hangover onset when evaluated by the elevated-plus maze and open field test respectively (p < 0.05). Fear-related behavior was detected in hangover animals by the increase of freezing and decrease of line crossings and rearing frequency during 16 h after hangover onset (p < 0.001). Depression signs were found in hangover mice during 14 h (p < 0.05). Hangover mice showed a significant decrease in pain perception when tested by tail immersion test at the beginning of hangover (p < 0.05). Our findings demonstrate a time-extension between 14 and 16 h for hangover affective impairments. This study shows the long lasting effects of hangover over the phase of ethanol intoxication.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Behavioural Brain Research - Volume 253, 15 September 2013, Pages 128-138
نویسندگان
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