کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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6260118 | 1290029 | 2010 | 8 صفحه PDF | دانلود رایگان |
The pedunculopontine nucleus (PPN) has been introduced only recently as a new target for deep brain stimulation (DBS) to treat gait disorders and postural instability in Parkinson's disease (PD). We here tested whether the 6-hydroxydopamine (6-OHDA) PD rat model can be used to study the pathophysiological mechanisms of DBS of the pedunculopontine tegmental nucleus (PPTg), the equivalent to the human PPN.In male Sprague-Dawley rats with unilateral 6-OHDA-induced nigrostriatal lesions and an electrode implanted into the ipsilateral PPTg the individual threshold for stimulation-induced side effects was higher for 25 than for 130Â Hz, and lower for lesioned compared to sham-lesioned controls. Rats were thus divided into four groups, (1) sham-stimulation, (2,3) 130Â Hz and 25Â Hz stimulation with the individual threshold determined for 130Â Hz, and (4) 25Â Hz stimulation at 20% below threshold (25Â Hz high). After 24Â h stimulation the rats were tested for limb use contralateral to the lesion (cylinder test and adhesive removal test), for locomotor activity (open field), and for postural instability (pole test).In lesioned rats 130Â Hz and 25Â Hz high stimulation improved postural instability in the pole test, but deteriorated limb use during adhesive removal. Additionally, 25Â Hz high deteriorated motor activity in the cylinder test and open field, while 25Â Hz stimulation marginally improved activity. Sham-lesioned rats were not affected by stimulation.Stimulation with different frequencies and intensities had complex effects on behavioral function tested. The present data provide foundation for future investigations on DBS of the PPTg in sensorimotor functions.
Journal: Behavioural Brain Research - Volume 210, Issue 1, 26 June 2010, Pages 46-53