کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6260168 | 1290055 | 2009 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Research reportAttenuation of morphine withdrawal signs by a GABAB receptor agonist in the locus coeruleus of rats
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
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چکیده انگلیسی
In the present study, the effects of intra-locus coeruleus (LC) injection of GABAB receptor-interacting agents on naloxone-induced withdrawal signs of morphine-dependent rats were examined. The GABAB receptor agonist and antagonists were injected 5Â min prior to naloxone injection. Baclofen, a GABAB receptor agonist, decreased the TWS in a dose-dependent manner but CGP35348, a GABAB receptor antagonist, alone had no effect. On the other hand, baclofen effects were reversed by CGP35348. It may be concluded that activation of GABAB receptor mechanisms in the LC reduces precipitated withdrawal symptoms from chronic morphine treatment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Behavioural Brain Research - Volume 196, Issue 1, 3 January 2009, Pages 11-14
Journal: Behavioural Brain Research - Volume 196, Issue 1, 3 January 2009, Pages 11-14
نویسندگان
Esmail Riahi, Iraj Mirzaii-Dizgah, Seyed Morteza Karimian, Hamid Reza Sadeghipour Roodsari, Ahmad Reza Dehpour,