کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6261541 1613231 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Research reportKetogenic diet prevents neuronal firing increase within the substantia nigra during pentylenetetrazole-induced seizure in rats
ترجمه فارسی عنوان
رژیم غذایی رژیم های غذایی باعث جلوگیری از افزایش شلیک عصبی در محرک عصبی در طول تشنج ناشی از پنتیلن تترازول در موش صحرایی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
چکیده انگلیسی


- The substantia nigra is involved in the threshold for seizure-induction.
- Ketogenic diets can decrease the reactivity of the substantia nigra.
- This effect could explain the anti-seizure action of ketogenic diets.

The mechanism responsible for the anti-seizure effect of ketogenic diets is poorly understood. Because the substantia nigra pars reticulata (SNr) is a “gate” center for seizures, the aim of the present experiment was to evaluate if a ketogenic diet modifies the neuronal response of this nucleus when a seizure-inducing drug is administered in rats. Two groups of rats were given a standard diet (group 1) or a ketogenic diet (group 2) for four weeks, then the threshold for seizure induction and the firing rate of putative GABAergic neurons within the SNr were evaluated with progressive infusion of pentylenetetrazole under general anesthesia. The results demonstrated that the ketogenic diet abolished the correlation between the firing rate response of SNr-neurons and the seizure-threshold. This result suggests that the anti-seizure effect of ketogenic diets can be due to a decrease in reactivity of GABAergic SNr-neurons.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research Bulletin - Volume 125, July 2016, Pages 168-172
نویسندگان
, , , , , , ,