کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6261801 | 1613250 | 2014 | 9 صفحه PDF | دانلود رایگان |
- MAPK/ERK activity in fear memory consolidation, reconsolidation and extinction.
- A possible role for MAPK/ERK in switching from memory formation to memory erasure.
- MAPK/ERK as a possible molecular target to develop treatments for anxiety disorders.
The highly conserved mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) signaling cascade is involved in several intracellular processes ranging from cell differentiation to proliferation, as well as in synaptic plasticity. In the last two decades, the role of MAPK/ERK in long-term memory formation in mammals, particularly in fear-related memories, has been extensively investigated.In this review we describe knowledge advancement on the role of MAPK/ERK in orchestrating the intracellular processes that lead to the consolidation, reconsolidation and extinction of fear memories. In doing so, we report studies in which the specific role of MAP/ERK in switching from memory formation to memory erasure has been suggested. The possibility to target MAPK/ERK in developing and/or refining pharmacological approaches to treat psychiatric disorders in which fear regulation is defective has also been envisaged.
Journal: Brain Research Bulletin - Volume 105, June 2014, Pages 8-16