کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6261818 1613263 2013 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Research ReportEffects of social housing on hippocampal dendrites and behavior in ovariectomized rats
ترجمه فارسی عنوان
تحقیقات گزارش شده اثرات مسکن اجتماعی بر جنین های هیپوکامپ و رفتار در موش های صحرایی تخمدان
کلمات کلیدی
افسردگی، استرس اجتماعی، دندریتهای هیپوکامپ، رفتار میدان باز، اضطراب،
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
چکیده انگلیسی

Social stress is both species and gender specific. For female rats, individual housing and social instability housing conditions are associated with behavioral indicators of stress and depression. The present study directly compared the effects of six weeks of individual housing, social instability and mixed sex, semi-crowded housing in a visible burrow system (VBS) on ovariectomized female rats. Paired, stable housing was used as the control. Behavioral tests were conducted two, four and six weeks into the housing manipulations and included sucrose consumption, social interest, and activity in the open field. Following a series of four behavioral tests, animals were sacrificed and brains were processed for Golgi impregnation. Basal dendrites of CA3 hippocampal neurons were measured. Results indicate that the individual housing and social instability groups were comparable to the control group for all measures. In contrast, the rats housed in the VBS exhibited reduced activity in open field testing, and alterations in social interest. Dendritic lengths were also reduced in those animals living in the VBS in comparison to the animals housed in pairs. To our knowledge, this is the first report of behavioral and neural effects of VBS housing on female rats. Further research is necessary to determine what facets of the VBS housing are responsible for the behavioral and neural changes.This article is part of a Special Issue entitled 'Animal Models'.

► Social stress is both species and gender specific. ► We explored the impact of three social housing conditions on behavior and hippocampal morphology in ovariectomized female rats. ► Semi-crowded, mixed sex housing in a visible burrow system was associated with behavioral and neuronal compromise.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research Bulletin - Volume 92, March 2013, Pages 69-75
نویسندگان
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