کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6262256 1613794 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Deep brain stimulation of the inferior colliculus in the rodent suppresses tinnitus
ترجمه فارسی عنوان
تحریک مغزی عمیق کولیکولوس پایین در جوندگان باعث خفگی وزوز گوش می شود
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی


- Noise-trauma induced tinnitus was assessed using gap induced prepulse inhibition.
- Deep brain stimulation was applied in the external cortex of inferior colliculus.
- Tinnitus-like behavior was significantly reduced during deep brain stimulation.
- Hearing seems not to be affected by deep brain stimulation.

In animal models of tinnitus pathological neuronal activity has been demonstrated. Deep brain stimulation disrupts pathological neuronal activity and might therefore be a potential treatment for patients who suffer severely from tinnitus. In this study, the effect of DBS in the inferior colliculi is investigated in an animal model of tinnitus. The external cortex of the inferior colliculus was targeted because of the key position of the inferior colliculus within the auditory network and the relation of the external cortex with the limbic system. In this study we show the effect of DBS in the inferior colliculus on tinnitus using a within-subject experimental design. After noise trauma, rats showed a significant increase in gap:no gap ratio of the gap-induced prepulse inhibition at 16 and 20 kHz (p<0.05), indicating the presence of tinnitus in these frequency bands. During DBS the gap:no gap ratio returned back to baseline (p<0.05). Hearing thresholds before and during DBS did not differ, indicating that hearing function is probably not impaired by electrical stimulation. In summary, this study shows that DBS of the inferior colliculi is effective in reducing behavioral signs of tinnitus in an animal model. Impaired hearing function could not be objectified as a side effect of stimulation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1650, 1 November 2016, Pages 118-124
نویسندگان
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