Research reportEffects of electromagnetic field exposure on conduction and concentration of voltage gated calcium channels: A Brownian dynamics study

- The effect of electromagnetic field radiation on conduction properties of voltage-gated Calcium ions has been investigated.
- The study is based on our developed comprehensive and complete computational. method.
- The results indicate the effects of exposure to EM: Growth of Calcium current; Lowering passage time of Calcium ions; Decreasing the concentration of Calcium in the channel; Increasing the amplitude of excitation for a specific frequency, will be resulted in growth of backward current while the inward current doesn't change significantly.

A three-dimensional Brownian Dynamics (BD) in combination with electrostatic calculations is employed to specifically study the effects of radiation of high frequency electromagnetic fields on the conduction and concentration profile of calcium ions inside the voltage-gated calcium channels. The electrostatic calculations are performed using COMSOL Multiphysics by considering dielectric interfaces effectively. The simulations are performed for different frequencies and intensities. The simulation results show the variations of conductance, average number of ions and the concentration profiles of ions inside the channels in response to high frequency radiation. The ionic current inside the channel increases in response to high frequency electromagnetic field radiation, and the concentration profiles show that the residency of ions in the channel decreases accordingly.

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