کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6262507 1292357 2016 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
ReviewThe scales and tales of myelination: using zebrafish and mouse to study myelinating glia
ترجمه فارسی عنوان
مقیاس و داستان های میلینین بررسی: با استفاده از پرورش ماهی و ماهی و موش برای مطالعه گلیا مینولینیت
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی


- Myelin is an evolutionary innovation of the jawed-vertebrate lineage.
- Many studies of myelin use mouse, but zebrafish are also a powerful model organism.
- This review compares myelinating glial cell biology during development and regeneration in zebrafish and mouse.

Myelin, the lipid-rich sheath that insulates axons to facilitate rapid conduction of action potentials, is an evolutionary innovation of the jawed-vertebrate lineage. Research efforts aimed at understanding the molecular mechanisms governing myelination have primarily focused on rodent models; however, with the advent of the zebrafish model system in the late twentieth century, the use of this genetically tractable, yet simpler vertebrate for studying myelination has steadily increased. In this review, we compare myelinating glial cell biology during development and regeneration in zebrafish and mouse and enumerate the advantages and disadvantages of using each model to study myelination.This article is part of a Special Issue entitled SI: Myelin Evolution.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1641, Part A, 15 June 2016, Pages 79-91
نویسندگان
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