کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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6262985 | 1613819 | 2015 | 11 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Research ReportLong-and short-range functional connectivity density alteration in non-alcoholic cirrhotic patients one month after liver transplantation: A resting-state fMRI study Research ReportLong-and short-range functional connectivity density alteration in non-alcoholic cirrhotic patients one month after liver transplantation: A resting-state fMRI study](/preview/png/6262985.png)
- Long- and short-range FCD partially reversed during the early period after LT.
- The FCD reduction of some radical components in default mode network and frontal lobe persisted in the early period after LT.
- ÎDST score positively correlated with long-range ÎFCD in right precentral gyrus and right supplementary motor area.
PurposeTo longitudinally evaluate long- and short-range functional connectivity density (FCD) alteration in cirrhotic patients one month after liver transplantation (LT) and their correlation with cognitive changes by using resting-state functional magnetic resonance imaging (rs-fMRI).MethodsTwenty seven candidates awaiting LT and 24 age-, gender-, and education-matched healthy controls (HCs) were studied. All 27 patients and HCs performed rs-fMRI examinations. Of 27 cirrhotic patients, 13 patients received LT underwent the repeated rs-fMRI examinations one month after LT. Laboratory and psychometric tests were carried out. The long- and short-range FCD maps derived from degree centrality calculation were compared. Correlations between FCD alteration and laboratory/psychometric changes were evaluated as well.ResultsIn cirrhotic patients, most of the brain areas with altered long- and short-range FCD could reverse one month after LT, which was accompanied with cognitive and liver functional improvement. The reduced long-range FCD in right posterior cingulate cortex (PCC) and Left middle frontal gyrus (MFG), and reduced short-range FCD in right precuneus (PCu) persisted in the early period after LT. In addition, one month after LT, the post-LT group showed reduced long-range FCD in right rectus gyrus (REC) and left medial prefrontal cortex (MPFC), and reduced short-range FCD in left middle temporal gyrus (MTG), when compared with the pre-LT group. We found Îdigital symbol test (ÎDST) score positively correlated with long-range ÎFCD in right precentral gyrus (preCG) (r=0.72, P<0.01) and right supplementary motor area (SMA) (r=0.59, P<0.05).ConclusionLT results in favorable effect on cognitive function in cirrhotic patient, which can be reflected by FCD alteration. However, persistence of PCC/PCu functional connectivity disturbance one month after LT indicates complete cognitive function restoration may need a longer time.
Journal: Brain Research - Volume 1620, 16 September 2015, Pages 177-187