کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6263013 1613823 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Research ReportThe accumulation of brain water-free sodium is associated with ischemic damage independent of the blood pressure in female rats
ترجمه فارسی عنوان
گزارش تحقیقات انباشت سدیم بدون آب مغز با عوارض ایسکمیک مستقل از فشار خون در موش های صحرایی ماده است
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی


- We examine the relation between brain water-free Na+ accumulation and ischemia.
- Both high-salt intake and estrogen deficiency accumulate brain water-free Na+.
- In female rats, brain water-free Na+ accumulation worsens ischemic brain damage.
- Na+ accumulation does not necessarily have effects on blood pressure in female rats.
- Eplerenone reduces both brain water-free Na+ accumulation and ischemic brain damage.

Estrogen deficiency worsens ischemic stroke outcomes. In ovariectomized (OVX+) rats fed a high-salt diet (HSD), an increase in the body Na+/water ratio, which characterizes water-free Na+ accumulation, was associated with detrimental vascular effects independent of the blood pressure (BP). We hypothesized that an increase in brain water-free Na+ accumulation is associated with ischemic brain damage in OVX+/HSD rats. To test our hypothesis we divided female Wistar rats into 4 groups, OVX+ and OVX− rats fed HSD or a normal diet (ND), and subjected them to transient cerebral ischemia. The brain Na+/water ratio was increased even in OVX+/ND rats and augmented in OVX+/HSD rats. The increase in the brain Na+/water ratio was positively correlated with expansion of the cortical infarct volume without affecting the BP. Interestingly, OVX+ was associated with the decreased expression of ATP1α3, a subtype of the Na+ efflux pump. HSD increased the expression of brain Na+ influx-related molecules and the mineralocorticoid receptor (MR). The pretreatment of OVX+/HSD rats with the MR antagonist eplerenone reduced brain water-free Na+ accumulation, up-regulated ATP1α3, down-regulated MR, and reduced the cortical infarct volume. Our findings show that the increase in the brain Na+/water ratio elicited by estrogen deficiency or HSD is associated with ischemic brain damage BP-independently, suggesting the importance of regulating the accumulation of brain water-free Na+. The up-regulation of ATP1α3 and the down-regulation of MR may provide a promising therapeutic strategy to attenuate ischemic brain damage in postmenopausal women.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1616, 7 August 2015, Pages 37-44
نویسندگان
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