کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6263309 1613855 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Research ReportPathological stress granules in Alzheimer's disease
ترجمه فارسی عنوان
گزارش تحقیقاتی گرانولهای استرس پاتولوژیک در بیماری آلزایمر
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی


- In Alzheimer's disease, pathological tau is associated with RNA binding proteins.
- The RNA binding proteins fulfill established criteria of stress granules.
- TIA-1 appears capable of inducing the appearance of inclusions with misfolded tau.

A feature of neurodegenerative disease is the accumulation of insoluble protein aggregates in the brain. In some conditions, including Amyotrophic Lateral Sclerosis and Frontotemporal lobar degeneration, the primary aggregating entities are RNA binding proteins. Through regulated prion-like assembly, RNA binding proteins serve many functions in RNA metabolism that are essential for the healthy maintenance of cells of the central nervous system. Those RNA binding proteins that are the core nucleating factors of stress granules (SGs), including TIA-1, TIAR, TTP and G3BP1, are also found in the pathological lesions of other neurological conditions, such as Alzheimer's disease, where the hallmark aggregating protein is not an RNA binding protein. This discovery suggests that the regulated cellular pathway, which utilizes assembly of RNA binding proteins to package and silence mRNAs during stress, may be integral in the aberrant pathological protein aggregation that occurs in numerous neurodegenerative conditions.This article is part of a Special Issue entitled RNA Metabolism 2013.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1584, 10 October 2014, Pages 52-58
نویسندگان
, , , , ,