کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6263551 | 1613902 | 2013 | 15 صفحه PDF | دانلود رایگان |
- RS-fMRI was performed at the sub-acute stage on mTBI patients with self-reported memory complaints.
- We examined the interactions between the Default Mode (DMN) and Task Positive Networks (TPN).
- Increased connectivity at rest between TPN, DMN, and SN observed in patients with memory issues.
- Connectivity changes correlate with neuropsychological changes.
- Changes in sub-acute stage rs-fMRI are consistent with the Default Mode Interference Hypothesis.
In this study we investigated the functional connectivity in 23 Mild TBI (mTBI) patients with and without memory complaints using resting state fMRI in the sub-acute stage of injury as well as a group of control participants. Results indicate that mTBI patients with memory complaints performed significantly worse than patients without memory complaints on tests assessing memory from the Automated Neuropsychological Assessment Metrics (ANAM). Altered functional connectivity was observed between the three groups between the default mode network (DMN) and the nodes of the task positive network (TPN). Altered functional connectivity was also observed between both the TPN and DMN and nodes associated with the Salience Network (SN). Following mTBI there is a reduction in anti-correlated networks for both those with and without memory complaints for the DMN, but only a reduction in the anti-correlated network in mTBI patients with memory complaints for the TPN. Furthermore, an increased functional connectivity between the TPN and SN appears to be associated with reduced performance on memory assessments. Overall the results suggest that a disruption in the segregation of the DMN and the TPN at rest may be mediated through both a direct pathway of increased FC between various nodes of the TPN and DMN, and through an indirect pathway that links the TPN and DMN through nodes of the SN. This disruption between networks may cause a detrimental impact on memory functioning following mTBI, supporting the Default Mode Interference Hypothesis in the context of mTBI related memory deficits.
Journal: Brain Research - Volume 1537, 6 November 2013, Pages 201-215