کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6263602 1613900 2013 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Depression, anxiety-like behavior and memory impairment are associated with increased oxidative stress and inflammation in a rat model of social stress
ترجمه فارسی عنوان
افسردگی، رفتار اضطرابی و اختلال حافظه با افزایش استرس اکسیداتیو و التهاب در یک مدل موش در استرس اجتماعی همراه است
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی


• Social defeat stress leads to anxiety-like and depression-like behaviors along with memory deficits in rats.
• Co-occurrence of anxiety–depression like behaviors and memory deficits in rats correlates with elevated oxidative stress.
• Potential cross-talk between oxidative stress and inflammation might regulate affected behaviors during social stress in rats.

In the present study, we have examined the behavioral and biochemical effect of induction of psychological stress using a modified version of the resident-intruder model for social stress (social defeat). At the end of the social defeat protocol, body weights, food and water intake were recorded, depression and anxiety-like behaviors as well as memory function was examined. Biochemical analysis including oxidative stress measurement, inflammatory markers and other molecular parameters, critical to behavioral effects were examined. We observed a significant decrease in the body weight in the socially defeated rats as compared to the controls. Furthermore, social defeat increased anxiety-like behavior and caused memory impairment in rats (P<0.05). Socially defeated rats made significantly more errors in long term memory tests (P<0.05) as compared to control rats. Furthermore, brain extracellular signal-regulated kinase-1/2 (ERK1/2), and an inflammatory marker, interleukin (IL)-6 were activated (P<0.05), while the protein levels of glyoxalase (GLO)-1, glutathione reductase (GSR)-1, calcium/calmodulin-dependent protein kinase type (CAMK)-IV, cAMP-response-element-binding protein (CREB) and brain-derived neurotrophic factor (BDNF) were significantly less (P<0.05) in the hippocampus, but not in the prefrontal cortex and amygdala of socially defeated rats, when compared to control rats. We suggest that social defeat stress alters ERK1/2, IL-6, GLO1, GSR1, CAMKIV, CREB, and BDNF levels in specific brain areas, leading to oxidative stress-induced anxiety–depression-like behaviors and as well as memory impairment in rats.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1539, 20 November 2013, Pages 73–86