کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6263972 1613944 2013 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Research ReportAltered cerebellar-cerebral resting-state functional connectivity reliably identifies major depressive disorder
ترجمه فارسی عنوان
گزارش پژوهش گزارش شده است اتصال به عملکرد حالت استراحت مغز و مغز، به طور قابل اعتماد، اختلال افسردگی عمده را تشخیص می دهد
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی

In recent years, the cerebellum has been demonstrated to be involved in cognitive control and emotional processing and to play an important role in the pathology of major depressive disorder (MDD). The current study aims to explore the potential utility of selecting the altered cerebellar-cerebral functional connectivity as a classification feature to discriminate depressed patients from healthy controls. Twenty-four medication-free patients with major depression and 29 matched, healthy controls underwent resting-state functional magnetic resonance imaging. A promising classification accuracy of 90.6% was achieved using resting-state functional connectivity between predefined cerebellar seed regions and the voxels within the cerebrum as features. Moreover, the most discriminating functional connections were mainly located between the cerebellum and the anterior cingulate cortex, the ventromedial prefrontal cortex, the ventrolateral prefrontal cortex, the temporal lobe and the fusiform gyrus, which may contribute to the emotional and cognitive impairments observed in major depression. The current findings imply that the cerebellum might be considered as a node in the distributed disease-related brain network in major depression.

► Cerebellar-cerebral connections reliably identify depressed patients from controls. ► The cerebellum is abnormally connected to the prefrontal and visual cortices. ► The altered cerebellar-cerebral connectivity implied neural deficits of depression. ► The cerebellum could be considered in the pathological model of depression.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1495, 7 February 2013, Pages 86-94
نویسندگان
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