Stress-induced altered cholinergic-glutamatergic interactions in the mouse hippocampus

► Cholinergic-glutamatergic interactions after stress were studied in the mouse hippocampus. ► Muscarinic-dependent release of glutamate was enhanced four weeks after stress. ► Pathway-specific (stratum oriens, not Schaffer collaterals) LTP was enhanced. ► Behavioral modulation by cholinergic drugs was altered. ► Conclusion: cholinergic modulation of glutamatergic transmission is enhanced after stress.