کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6264237 1613969 2012 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Research ReportEnvironmental enrichment restores cognitive deficits induced by prenatal maternal seizure
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Research ReportEnvironmental enrichment restores cognitive deficits induced by prenatal maternal seizure
چکیده انگلیسی

Maternal seizure has adverse effects on brain histology as well as on learning and memory ability in progeny. An enriched environment (EE) is known to promote structural changes in the brain and improve cognitive and motor deficits following a variety of brain injuries. Whether EE treatment in early postnatal periods could restore cognitive impairment induced by prenatal maternal seizure is unknown. Adult female Sprague-Dawley rats were randomly separated into two groups and were injected intraperitoneally either saline or pentylenetetrazol (PTZ) for 30 days. Then the fully kindled rats and control animals were allowed to mate. PTZ administration was continued until delivery, while the control group received saline at the same time. After weaning at postnatal day 22, one-half of the male offspring in the control and in the prenatal maternal group were given the environmental enrichment treatment through all the experiments until they were tested. Morris water maze testing was performed at 8 weeks of age. Western blot and synaptic ultrastructure analysis were then performed. We found that EE treatment reversed spatial learning deficits induced by prenatal maternal seizure. An EE also reversed the changes in synaptic ultrastructure following prenatal maternal seizure. In addition, prenatal maternal seizure significantly decreased phosphorylation states of cAMP response element binding (CREB) in the hippocampus, whereas EE reversed this reduced expression. These findings suggest that EE treatment on early postnatal periods could be a potential therapy for improving cognitive deficits induced by prenatal maternal seizure.

► EE treatment reversed cognitive impairment induced by prenatal maternal seizure. ► EE treatment reversed the changes of synaptic ultrastructure in the hippocampus. ► EE treatment reversed the reduced p-CREB induced by prenatal maternal seizure.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1470, 27 August 2012, Pages 80-88
نویسندگان
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