کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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6264558 | 1614003 | 2012 | 10 صفحه PDF | دانلود رایگان |
Spike-wave discharges (SWD) are electroencephalographic hallmarks of absence epilepsy. SWD are known to originate from thalamo-cortical neuronal network that normally produces sleep spindle oscillations. Although sleep spindles and SWD are considered as thalamo-cortical oscillations, functional relationship between them is not obvious. The present study describes temporal dynamics of SWD and sleep spindles as determined in 24Â h EEG recorded in WAG/Rij rat model of absence epilepsy. SWD, sleep spindles (10-15Â Hz) and 5-9Â Hz oscillations were automatically detected in EEG using wavelet-based algorithm. It was found that non-linear dynamics of SWD fitted well to the law of 'on-off intermittency'. Sleep spindles also demonstrated 'on-off intermittency', in contrast to 5-9Â Hz oscillations, whose dynamics could not be classified as having any known type of non-linear behavior. Intermittency in sleep spindles and SWD implies that (1) temporal dynamics of these oscillations are deterministic in nature, and (2) it might be controlled by a system-level mechanism responsible for circadian modulation of neuronal network activity.
⺠Spike-wave discharges (SWD) are EEG manifestation of absence epilepsy. ⺠Sleep spindles, SWD 5-9 Hz oscillations were examined in EEG in WAG/Rij rats. ⺠Temporal dynamics of sleep spindles and SWD demonstrated 'on-off intermittency'. ⺠Dynamics of 5-9 Hz oscillations represented an unknown type of non-linear behavior.
Journal: Brain Research - Volume 1436, 3 February 2012, Pages 147-156