کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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6264655 | 1614010 | 2012 | 11 صفحه PDF | دانلود رایگان |

Granisetron, a serotonin 5-HT3 receptor antagonist, widely used as an antiemetic drug following chemotherapy, has been found to improve learning and memory. In this study, effects of granisetron on spatial recognition memory and fear memory and the involvement of nitric oxide (NO) have been determined in a Y-maze and passive avoidance test. Granisetron (3, 10Â mg/kg, intraperitoneally) was administered to scopolamine-induced memory-impaired mice prior to acquisition, consolidation and retrieval phases, either in the presence or in the absence of a non-specific NO synthase inhibitor, l-NAME (3, 10Â mg/kg, intraperitoneally); a specific inducible NO synthase (iNOS) inhibitor, aminoguanidine (100Â mg/kg); and a NO precursor, l-arginine (750Â mg/kg). It is demonstrated that granisetron improved memory acquisition in a dose-dependent manner, but it was ineffective on consolidation and retrieval phases of memory. The beneficial effect of granisetron (10Â mg/kg) on memory acquisition was significantly reversed by l-NAME (10Â mg/kg) and aminoguanidine (100Â mg/kg); however, l-arginine (750Â mg/kg) did not potentiate the effect of sub-effective dose of granisetron (3Â mg/kg) in memory acquisition phase. It is concluded that nitric oxide is probably involved in improvement of memory acquisition by granisetron in both spatial recognition memory and fear memory.This article is part of a Special Issue entitled The Cognitive Neuroscience.
⺠Granisetron improves acquisition in scopolamine-induced memory impaired mice. ⺠NOS inhibitors reverse this effect in acquisition of fear and spatial memory. ⺠L-arginine dose not potentiate this effect. ⺠NO is probably involved in this enhancement.
Journal: Brain Research - Volume 1429, 6 January 2012, Pages 61-71