کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6264655 1614010 2012 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Research ReportInvolvement of nitric oxide in granisetron improving effect on scopolamine-induced memory impairment in mice
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Research ReportInvolvement of nitric oxide in granisetron improving effect on scopolamine-induced memory impairment in mice
چکیده انگلیسی

Granisetron, a serotonin 5-HT3 receptor antagonist, widely used as an antiemetic drug following chemotherapy, has been found to improve learning and memory. In this study, effects of granisetron on spatial recognition memory and fear memory and the involvement of nitric oxide (NO) have been determined in a Y-maze and passive avoidance test. Granisetron (3, 10 mg/kg, intraperitoneally) was administered to scopolamine-induced memory-impaired mice prior to acquisition, consolidation and retrieval phases, either in the presence or in the absence of a non-specific NO synthase inhibitor, l-NAME (3, 10 mg/kg, intraperitoneally); a specific inducible NO synthase (iNOS) inhibitor, aminoguanidine (100 mg/kg); and a NO precursor, l-arginine (750 mg/kg). It is demonstrated that granisetron improved memory acquisition in a dose-dependent manner, but it was ineffective on consolidation and retrieval phases of memory. The beneficial effect of granisetron (10 mg/kg) on memory acquisition was significantly reversed by l-NAME (10 mg/kg) and aminoguanidine (100 mg/kg); however, l-arginine (750 mg/kg) did not potentiate the effect of sub-effective dose of granisetron (3 mg/kg) in memory acquisition phase. It is concluded that nitric oxide is probably involved in improvement of memory acquisition by granisetron in both spatial recognition memory and fear memory.This article is part of a Special Issue entitled The Cognitive Neuroscience.

► Granisetron improves acquisition in scopolamine-induced memory impaired mice. ► NOS inhibitors reverse this effect in acquisition of fear and spatial memory. ► L-arginine dose not potentiate this effect. ► NO is probably involved in this enhancement.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1429, 6 January 2012, Pages 61-71
نویسندگان
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