کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6264863 1614051 2011 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Research ReportMethylphenidate does not improve interference control during a working memory task in young patients with attention-deficit hyperactivity disorder
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Research ReportMethylphenidate does not improve interference control during a working memory task in young patients with attention-deficit hyperactivity disorder
چکیده انگلیسی

Patients with attention-deficit/hyperactivity disorder (ADHD) show deficits in working memory (WM) which may be related to prefrontal dysfunction. Methylphenidate (MPH) can restore WM deficits in ADHD by enhancing prefrontal activity. At the same time, changes in striatal activation could cause ADHD patients to be more interference-sensitive during working memory tasks. However, it is unclear whether MPH reduces WM distractibility in ADHD. In this fMRI study, 12 ADHD patients and 12 healthy controls participated on two separate days in a delayed-match-to-sample test. During the delay interval, a distractor stimulus was presented in half of the trials. Children and adolescents with ADHD received MPH only on one of the two sessions. Behavioral data analyses revealed that MPH normalized WM in ADHD. However, MPH did not improve WM performance when a distractor was presented during the delay interval. Functional images showed that MPH enhanced prefrontal activity during the delay in ADHD patients when no distractor was present. If the delay was interrupted by a distractor, only healthy controls showed activation of the caudate. In patients with ADHD, however, in line with behavioral data, MPH did not enhance caudate activity. In healthy youth, caudate activity is involved in interference control allowing the successful maintenance of information in working memory even in the presence of distraction. Our findings suggest that interference control, linked to caudate activity, is not adequately enhanced by MPH in ADHD.

Research Highlights► In ADHD, MPH has differential effect on WM. ► MPH enhanced prefrontal activity and normalized WM without interference. ► MPH had no impact on deviant WM with interference. ► Only in controls, caudate activity was associated with interference control. ► In ADHD, MPH did not enhance activity in caudate.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1388, 4 May 2011, Pages 56-68
نویسندگان
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