کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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6264993 | 1614054 | 2011 | 6 صفحه PDF | دانلود رایگان |

Previously we demonstrated that Osthole, a natural coumarin, protects against focal cerebral ischemia/reperfusion-induced injury in rats. In the present study, the effects of Osthole on neurobehavioral functions, infarct volume and matrix metalloproteinase-9 (MMP-9) in a rat 2Â h focal cerebral ischemia model were investigated. Osthole (100Â mg/kg per dose) was administrated intraperitoneally 30Â min before ischemic insult and immediately after reperfusion. Osthole treatment significantly reduced neurological deficit score and infarct volume by 38.5% and 33.8%, respectively, as compared with the untreated animals. Osthole reversed ischemia-reperfusion-induced increase in MMP-9 protein level/activity as evidenced by Western blotting and gelatin zymography. Taken together, these results for the first time demonstrate that Osthole reduces infarct volume, restores neurobehavioral functions and downregulates MMP-9 protein level/activity in ischemia/reperfused brain.
Research highlightsâºOsthole has neuroprotective effects against acute brain ischemia. âºOsthole reverses ischemia-reperfusion-induced increase in MMP-9 protein. âºOsthole inhibits MMP-9 activity in rat ischemia-reperfused brain.
Journal: Brain Research - Volume 1385, 18 April 2011, Pages 275-280