کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6265053 1614057 2011 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Research ReportSalidroside protects against MPP+-induced apoptosis in PC12 cells by inhibiting the NO pathway
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Research ReportSalidroside protects against MPP+-induced apoptosis in PC12 cells by inhibiting the NO pathway
چکیده انگلیسی

Oxidative stress plays an important role in Parkinson's disease and other neurodegenerative disorders. Salidroside, a phenylpropanoid glycoside isolated from Rhodiola rosea L., has potent antioxidant properties. In the present study, we investigated the protective activity of salidroside against 1-methyl-4-phenylpyridinium (MPP+)-induced apoptosis in PC12 cells. We found that incubation of PC12 cells with salidroside prior to MPP+ exposure significantly reduced cell apoptosis and attenuated collapse of the mitochondrial membrane potential (MMP). Furthermore, salidroside inhibited the MPP+-induced nitric oxide (NO) increase and overexpression of nNOS and iNOS and suppressed accumulation of reactive oxygen species (ROS) and intracellular free Ca2+. Our results show that the protective effects of salidroside on PC12 cells are mediated, at least in part, by inhibition of the NO pathway.

Research Highlights► NO plays an important role in the pathogenesis of PD. ► NO can mediate neurotoxicity and cause neuronal cell death. ► Salidroside have strong antioxidant and neuroprotectant. ► Salidroside are protective for the pc12 cells against MPP+ intoxication. ► Salidroside can possibly be used as a neuroprotective agent for treatment of PD.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1382, 25 March 2011, Pages 9-18
نویسندگان
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