کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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6265053 | 1614057 | 2011 | 10 صفحه PDF | دانلود رایگان |

Oxidative stress plays an important role in Parkinson's disease and other neurodegenerative disorders. Salidroside, a phenylpropanoid glycoside isolated from Rhodiola rosea L., has potent antioxidant properties. In the present study, we investigated the protective activity of salidroside against 1-methyl-4-phenylpyridinium (MPP+)-induced apoptosis in PC12 cells. We found that incubation of PC12 cells with salidroside prior to MPP+ exposure significantly reduced cell apoptosis and attenuated collapse of the mitochondrial membrane potential (MMP). Furthermore, salidroside inhibited the MPP+-induced nitric oxide (NO) increase and overexpression of nNOS and iNOS and suppressed accumulation of reactive oxygen species (ROS) and intracellular free Ca2+. Our results show that the protective effects of salidroside on PC12 cells are mediated, at least in part, by inhibition of the NO pathway.
Research Highlights⺠NO plays an important role in the pathogenesis of PD. ⺠NO can mediate neurotoxicity and cause neuronal cell death. ⺠Salidroside have strong antioxidant and neuroprotectant. ⺠Salidroside are protective for the pc12 cells against MPP+ intoxication. ⺠Salidroside can possibly be used as a neuroprotective agent for treatment of PD.
Journal: Brain Research - Volume 1382, 25 March 2011, Pages 9-18