کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6265129 | 1614068 | 2011 | 8 صفحه PDF | دانلود رایگان |
In the present study, we describe the cardiovascular effects of local acetylcholine (Ach) microinjection into both the ventrolateral (vlPAG) and dorsal (dPAG) periaqueductal gray areas of anesthetized rats and the possible local receptors involved with these responses. Microinjection of Ach (9, 27, 45 or 81Â nmol/50Â nL) into the vlPAG caused dose-related depressor responses. These hypotensive responses were blocked by local pretreatment with increasing doses of the nonselective muscarinic antagonist atropine (1, 3 or 9Â nmol/50Â nL). The microinjection of Ach into the dPAG caused no significant cardiovascular responses in anesthetized rats. In conclusion, the present findings suggest that a cholinergic system present in the vlPAG, but not in the dPAG, is involved with cardiovascular system control. Moreover, these cardiovascular responses evoked by Ach are mediated by muscarinic receptors.
Research Highlights⺠Microinjection of different doses of Ach into the vlPAG caused depressor response. ⺠The depressor response was blocked by muscarinic antagonist atropine. ⺠Microinjection of Ach into the dPAG caused no cardiovascular responses.
Journal: Brain Research - Volume 1371, 31 January 2011, Pages 74-81