کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6265267 1614069 2011 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Research ReportCircadian modulation of interval timing in mice
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Research ReportCircadian modulation of interval timing in mice
چکیده انگلیسی

Temporal perception is fundamental to environmental adaptation in humans and other animals. To deal with timing and time perception, organisms have developed multiple systems that are active over a broad range of order of magnitude, the most important being circadian timing, interval timing and millisecond timing. The circadian pacemaker is located in the suprachiasmatic nuclei (SCN) of the hypothalamus, and is driven by a self-sustaining oscillator with a period close to 24 h. Time estimation in the second-to-minutes range - known as interval timing - involves the interaction of the basal ganglia and the prefrontal cortex. In this work we tested the hypothesis that interval timing in mice is sensitive to circadian modulations. Animals were trained following the peak-interval (PI) procedure. Results show significant differences in the estimation of 24-second intervals at different times of day, with a higher accuracy in the group trained at night, which were maintained under constant dark (DD) conditions. Interval timing was also studied in animals under constant light (LL) conditions, which abolish circadian rhythmicity. Mice under LL conditions were unable to acquire temporal control in the peak interval procedure. Moreover, short time estimation in animals subjected to circadian desynchronizations (modeling jet lag-like situations) was also affected. Taken together, our results indicate that short-time estimation is modulated by the circadian clock.

Research Highlights► Interval timing in mice is modulated by the circadian system. ► Interval timing accuracy is better at night, both under LD and DD conditions. ► Interval timing performance is severely decreased under LL conditions. ► Interval timing performance is affected by circadian desynchronization.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1370, 25 January 2011, Pages 154-163
نویسندگان
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