کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6265326 1614072 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Research ReportOlfactory bulbectomy impairs the feeding response to 2-deoxy-d-glucose in rats
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Research ReportOlfactory bulbectomy impairs the feeding response to 2-deoxy-d-glucose in rats
چکیده انگلیسی

An early study reported that, unlike sham-operated rats, rats made anosmic by olfactory bulbectomy (OBX) failed to compensate for the dilution of their diet with nonnutritive bulk by increasing their food intake. In the present study, the effects of a glucoprivic challenge, intraperitoneal-administered 350 mg/kg 2-deoxy-d-glucose (2-DG), on food intake were measured in OBX and sham-operated female rats. Sham-operated rats significantly increased their food intake, but in two separate experiments OBX rats displayed no increase in food intake during the first 2 h following administration. Blood glucose levels were nearly identical in both groups. Body weights and daily food intakes of OBX rats did not differ from the sham-operated controls throughout the studies. Bulbectomized rats also displayed a normal drinking response after an intraperitoneal injection of 1 M hypertonic saline. Hypothalamic nuclei and the neural pathways mediating taste have been implicated in the feeding response to 2-DG. The present results suggest that olfactory input and olfactory neural pathways also mediate, at least in part, the feeding response to a glucoprivic challenge induced by intraperitoneal injection of 2-DG.

Research Highlights►First study to examine the effects of a glucoprivic challenge in rats with olfactory bulbectomies; ►One of the first studies to look at the effect of olfactory bulbectomy on feeding behavior in rats; ►Examines the effects of olfactory bulbectomy on the drinking response to an injection of hypertonic saline.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1367, 7 January 2011, Pages 207-212
نویسندگان
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