NEDD9 is genetically associated with Alzheimer's disease in a Han Chinese population

►Significant difference was found in genotype (P = 0.003) and allele (P = 0.002) frequencies of the SNP rs760678 within NEDD9 between LOAD patients and controls. ►The C-carrying genotype (GC + CC) individuals showed a 2.25-fold increased risk compared with the GG genotype carriers (P = 0.001). ►The C allele of rs760678 was only significantly associated with LOAD in non-APOE ε4 allele carriers (P = 0.024). ►rs760678 polymorphism was still strongly associated with LOAD after adjustment for age, gender, and the APOEε4 carrier status.