کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6265866 1614284 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Involvement of Y5 receptors in neuropeptide Y agonist-induced analgesic-like effect in the rat hot plate test
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Involvement of Y5 receptors in neuropeptide Y agonist-induced analgesic-like effect in the rat hot plate test
چکیده انگلیسی
Neuropeptide Y (NPY) induces analgesic-like effects after central administration across diverse pain models in rodents. In spinal pain models, previous studies indicate a prominent role for Y1 receptors at mediating this effect of NPY. In supraspinal pain models like the hot plate test, the NPY receptors involved have not been thoroughly explored. By intracerebroventricular (i.c.v.) administration of selective NPY receptor ligands, the possible involvement of Y5 receptors in analgesic-like mechanisms was investigated using the hot plate test in rats. Both NPY and selective Y5 agonists induced analgesic-like effects as revealed by prolonged hot plate latencies. Further consistent with a role for Y5 receptors, pretreatment with a selective Y5 receptor antagonist blocked the Y5 agonist-induced analgesic-like effect. The present study indicates involvement of Y5 receptors probably at the supraspinal level in mediation of NPY agonist-induced analgesic-like effects in the hot plate test.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1155, 25 June 2007, Pages 49-55
نویسندگان
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