کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6266697 | 1614523 | 2014 | 7 صفحه PDF | دانلود رایگان |
- Metabotropic GABAB receptors can, unexpectedly, mediate rapid termination of persistent network activity in the cortex.
- Layer 1 interneurons modulate network activity by targeting GABAB receptors on principal cells.
- Dendritic GABAB receptors can inhibit the firing of principal cells by acting on voltage-gated calcium channels.
Convention holds that ionotropic receptors mediate fast neurotransmission and that 'slow' G-protein coupled metabotropic receptors have a secondary, modulatory role in the control of neuronal networks. Here, we discuss recent evidence showing that activation of metabotropic GABAB receptors in cortical layer 1 can powerfully inhibit principal cell activity and that their activation can rapidly halt ongoing network activity. Inputs from both within and outwith the cortex converge upon layer 1 where they target various populations of interneurons, including neurogliaform cells. We argue that neurogliaform cells are the main effector of a powerful inhibitory circuit that, acting through GABAB receptors, can be differentially recruited by long-range connections to serve in roles as diverse as conscious perception and memory consolidation.
Journal: Current Opinion in Neurobiology - Volume 26, June 2014, Pages 15-21