کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6266723 1614523 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
From circuit motifs to computations: mapping the behavioral repertoire of cortical interneurons
ترجمه فارسی عنوان
از الگوی مدار به محاسبات: نقشه برداری روندهای رفتاری بینهایین کورتنی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی
The exquisite architecture of cortex incorporates a myriad of inhibitory interneuron types. Until recently, the dearth of techniques for cell type identification in awake animals has made it difficult to link interneuron activity with circuit function, computation and behavior. This situation has changed dramatically in recent years with the advent of novel tools for targeting genetically distinct interneuron types so their activity can be observed and manipulated. The association of different interneuron subtypes with specific circuit functions, such as gain modulation or disinhibition, is starting to reveal canonical circuit motifs conserved across neocortical regions. Moreover, it appears that some interneuron types are recruited at specific behavioral events and likely control the flow of information among and within brain areas at behavioral time scales. Based on these results we propose that interneuron function goes beyond network coordination and interneurons should be viewed as integral elements of cortical computations serving behavior.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Neurobiology - Volume 26, June 2014, Pages 117-124
نویسندگان
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