Neural mechanisms for filtering self-generated sensory signals in cerebellum-like circuits

This review focuses on recent progress in understanding mechanisms for filtering self-generated sensory signals in cerebellum-like circuits in fish and mammals. Recent in vitro studies in weakly electric gymnotid fish have explored the interplay among anti-Hebbian plasticity, synaptic dynamics, and feedforward inhibition in canceling self-generated electrosensory inputs. Studies of the mammalian dorsal cochlear nucleus have revealed multimodal integration and anti-Hebbian plasticity, suggesting that this circuit may adaptively filter incoming auditory information. In vivo studies in weakly electric mormryid fish suggest a key role for granule cell coding in sensory filtering. The clear links between synaptic plasticity and systems level sensory filtering in cerebellum-like circuits may provide insights into hypothesized adaptive filtering functions of the cerebellum itself.

► Cerebellum-like circuits in fish use plasticity to cancel predictable inputs. ► Plasticity mechanisms in different cerebellum-like circuits are compared. ► First evidence for multimodal integration in granule cells is reviewed. ► Implications for predictions in the cerebellum are discussed.