کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6266965 | 1614525 | 2014 | 14 صفحه PDF | دانلود رایگان |
- Astrocyte domains tile the cortex.
- Astrocytes are implicated in several forms of cortical developmental plasticity.
- Astrocytes are involved in cholinergic adult cortical plasticity.
Astrocytes are a multifunctional cell type in the nervous system that can influence neurons and synapses in numerous ways. Astrocytes have been suggested to play important roles in synapse formation during development, as well as in multiple forms of synaptic plasticity in the developing and adult brain. Astrocytes respond to nearby neural activity with elevations in cytosolic calcium concentration, and in sensory cortex these calcium responses have been shown to be topographically aligned to neuronal sensory maps. Here, we review recent evidence for astrocyte interactions with neural circuits, with particular emphasis on how these interactions may shape the development, arrangement and plasticity of cortical sensory maps.
Journal: Current Opinion in Neurobiology - Volume 24, February 2014, Pages 176-189